Preliminary Study on Delta-9-Tetrahydrocannabinol (∆9-THC): Hemispheric Lateralization with Behavioural Changes

Authors

  • Noor Azuin Suliman Universiti Putra Malaysia
  • Che Norma Mat Taib Universiti Putra Malaysia
  • Mohamad Aris Mohd Moklas Universiti Putra Malaysia
  • Zainul Amiruddin Zakaria Universiti Putra Malaysia

Keywords:

Delta-9-Tetrahydrocannabinol (∆9-THC), hemispheric lateralization, assymmetric

Abstract

This study is designed inspired by the fact that there is an interhemisphere asymmetry of the brain region. A lot of researches studied in demonstrating the differences between right and left hemispheres of the brain. The objective of this preliminary study is to observe scientifically the effect of delta-9-tetrahydrocannabinol (∆9-THC) on the hemispheric lateralization with behavioural changes. Two regions of brain are selected, prefrontal cortex and hippocampus. Behavioural tests, namely heat stress test and novel-object discrimination test (NOD), were done on day seven. The hippocampus and prefrontal cortex regions of the brain were preceded to Western Blot technique in detecting c-fos. As for behavioural tests, heat stress and NOD and c-fos on hippocampus did not show significant differences. Meanwhile, the prefrontal cortex shows significant difference with p < 0.01. With these findings, reasonable dosages of ∆9-THC should be used to have statistically significant differences effects on behavioural tests. 

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Author Biographies

  • Noor Azuin Suliman, Universiti Putra Malaysia
    Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia
  • Che Norma Mat Taib, Universiti Putra Malaysia
    Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia
  • Mohamad Aris Mohd Moklas, Universiti Putra Malaysia
    Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia
  • Zainul Amiruddin Zakaria, Universiti Putra Malaysia
    Department of Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia

Published

01-01-2014

Issue

Section

Articles

How to Cite

Suliman, N. A., Mat Taib, C. N., Mohd Moklas, M. A., & Zakaria, Z. A. (2014). Preliminary Study on Delta-9-Tetrahydrocannabinol (∆9-THC): Hemispheric Lateralization with Behavioural Changes. Journal of Science and Technology, 5(2). https://penerbit.uthm.edu.my/ojs/index.php/JST/article/view/545