Preliminary Study on Delta-9-Tetrahydrocannabinol (∆9-THC): Hemispheric Lateralization with Behavioural Changes

Noor Azuin Suliman, Che Norma Mat Taib, Mohamad Aris Mohd Moklas, Zainul Amiruddin Zakaria


This study is designed inspired by the fact that there is an interhemisphere asymmetry of the brain region. A lot of researches studied in demonstrating the differences between right and left hemispheres of the brain. The objective of this preliminary study is to observe scientifically the effect of delta-9-tetrahydrocannabinol (∆9-THC) on the hemispheric lateralization with behavioural changes. Two regions of brain are selected, prefrontal cortex and hippocampus. Behavioural tests, namely heat stress test and novel-object discrimination test (NOD), were done on day seven. The hippocampus and prefrontal cortex regions of the brain were preceded to Western Blot technique in detecting c-fos. As for behavioural tests, heat stress and NOD and c-fos on hippocampus did not show significant differences. Meanwhile, the prefrontal cortex shows significant difference with p < 0.01. With these findings, reasonable dosages of ∆9-THC should be used to have statistically significant differences effects on behavioural tests. 


Delta-9-Tetrahydrocannabinol (∆9-THC); hemispheric lateralization; assymmetric

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